Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470686 | 0.87 | MAPT (0.48) | ATMNPY5RALDH1A1KDM4ETSHR | |
| SCHEMBL27844158 | 0.86 | NPY5R (0.45) | ATMNPY5RALDH1A1KDM4ETSHR | |
| SCHEMBL3465527 | 0.83 | KMT2A (0.55) | NPY5RALDH1A1KDM4ETSHRHSD17B10 | |
| SCHEMBL9200019 | 0.80 | MTNR1A (0.60) | ATMALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL5449877 | 0.80 | ATM (0.57) | ATMALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL19674140 | 0.80 | ATM (0.57) | ATMALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14876504 | 0.79 | NTSR1 (0.57) | ATMALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL21810428 | 0.79 | NTSR1 (0.57) | ATMPRMT5MTNR1AMTNR1BHDAC11 | |
| SCHEMBL5637363 | 0.79 | ATM (0.56) | ATMALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL13699062 | 0.78 | PPARG (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103384661-A | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME | 2013-11-06 | — | — | CN | claimed |
| CN-103384661-B | Mineralocorticoid receptor antagonists | 默沙东公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-103384661-A | Mineralocorticoid receptor antagonists | MERCK SHARP & DOHME | 2013-11-06 | — | — | CN | disclosed |
| US-6043257-A | ANTICOAGULANT; PYRIDINE SUBSTITUTED INDAZOLE COMPOUND | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-03-28 | — | — | US | disclosed |
| US-5886191-A | ANTICOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 1999-03-23 | — | — | US | disclosed |