Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029887 | 0.85 | SIGMAR1 (0.83) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8033233 | 0.81 | SIGMAR1 (0.76) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL31061719 | 0.81 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8031431 | 0.81 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8035733 | 0.77 | HTR1A (0.67) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8035775 | 0.77 | SIGMAR1 (0.81) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8031447 | 0.77 | SIGMAR1 (0.81) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8029628 | 0.77 | SIGMAR1 (0.81) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8035829 | 0.76 | HTR1A (0.65) | SIGMAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8031437 | 0.75 | ADRA2B (0.60) | SIGMAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5691340-A | CENTRAL NERVOUS SYSTEM DISORDERS, STROKES, CARDIOVASCULAR DISORDERS, ALZHEIMER*S DISEASE OR ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-11-25 | — | — | US | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |