Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035829 | 0.81 | HTR1A (0.65) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL8031431 | 0.80 | SIGMAR1 (1.00) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL31061719 | 0.80 | SIGMAR1 (1.00) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL8029629 | 0.77 | SIGMAR1 (0.67) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL8029887 | 0.77 | SIGMAR1 (0.83) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL21092001 | 0.77 | NFKB1 (0.54) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL21091998 | 0.77 | NFKB1 (0.54) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL7343329 | 0.77 | HTR1A (0.71) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL8029628 | 0.76 | SIGMAR1 (0.81) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C | |
| SCHEMBL8031447 | 0.76 | SIGMAR1 (0.81) | HTR1ASIGMAR1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |