Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029920 | 0.87 | LTA4H (0.65) | SIGMAR1ATMLTA4HKDM4EKMT2A | |
| SCHEMBL8035768 | 0.86 | SIGMAR1 (0.57) | SIGMAR1ATMLTA4HKDM4EALDH1A1 | |
| SCHEMBL8033251 | 0.83 | CYP2D6 (0.57) | CYP2D6CYP2C9ALOX15TSHRCYP2C19 | |
| SCHEMBL8035719 | 0.79 | LTA4H (0.63) | SIGMAR1ATMLTA4HKDM4EALDH1A1 | |
| SCHEMBL8020078 | 0.78 | LTA4H (0.65) | SIGMAR1ATMLTA4HKDM4EKMT2A | |
| SCHEMBL8029621 | 0.78 | LTA4H (0.61) | SIGMAR1ATMLTA4HKDM4EALDH1A1 | |
| SCHEMBL8035796 | 0.78 | SIGMAR1 (0.68) | SIGMAR1LTA4HKDM4EKMT2AALDH1A1 | |
| SCHEMBL8029900 | 0.78 | LTA4H (0.57) | SIGMAR1ATMLTA4HKMT2AMEN1 | |
| SCHEMBL8020087 | 0.77 | MAPK1 (0.60) | SIGMAR1CYP2D6CYP2C9TSHRCYP2C19 | |
| SCHEMBL16225922 | 0.76 | ALDH1A1 (0.74) | SIGMAR1KMT2AALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |