Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046130 | 0.85 | ALDH1A1 (0.50) | TSHRALDH1A1GAAEPHX1 | |
| SCHEMBL8045590 | 0.81 | HSD11B1 (0.44) | TSHRHSD17B10ALDH1A1KDM4EGAA | |
| SCHEMBL23423425 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAAEPHX1 | |
| SCHEMBL3780624 | 0.78 | ALOX15 (0.63) | TSHRALOX15HSD17B10ALDH1A1KDM4E | |
| SCHEMBL8041290 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAEPHX1LMNA | |
| SCHEMBL8045110 | 0.76 | SIGMAR1 (0.57) | TSHRALDH1A1EPHX1LMNAHSD11B1 | |
| SCHEMBL31717947 | 0.74 | HSD17B10 (1.00) | TSHRALOX15HSD17B10ALDH1A1KDM4E | |
| SCHEMBL7389458 | 0.74 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL3774303 | 0.74 | ALDH1A1 (0.76) | TSHRALOX15HSD17B10ALDH1A1KDM4E | |
| SCHEMBL8044995 | 0.73 | CHRM5 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |