Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045590 | 0.82 | HSD11B1 (0.44) | SIGMAR1HSD11B1ALDH1A1TSHRTP53 | |
| SCHEMBL8043275 | 0.81 | ALDH1A1 (0.57) | SIGMAR1HSD11B1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8047476 | 0.79 | CHRM5 (0.48) | SIGMAR1 | |
| SCHEMBL8044995 | 0.79 | CHRM5 (0.48) | SIGMAR1 | |
| SCHEMBL8033603 | 0.78 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1 | |
| SCHEMBL8139508 | 0.77 | HSD11B1 (0.60) | SIGMAR1HSD11B1ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL8030934 | 0.76 | TSHR (0.55) | HSD11B1ALDH1A1TSHRSMN1; SMN2LMNA | |
| SCHEMBL8044535 | 0.76 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1 | |
| SCHEMBL13661593 | 0.73 | CARM1 (0.45) | SIGMAR1ALDH1A1 | |
| SCHEMBL8046130 | 0.73 | ALDH1A1 (0.50) | ALDH1A1TSHRHPGDEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |