Tetrahydrofolate

Tetrahydrofolate

SCHEMBL8031

Nc1nc(=O)c2c([nH]1)NC[C@@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)N2

nearest known ligand 0.78

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SOST Q9BQB4 1/20 0.78
▸ FPGS Q05932 2/20 0.69
▸ ATIC P31939 2/20 0.60
▸ GART P22102 4/20 0.58
▸ DHFR P00374 2/20 0.57
▸ MTHFD1 P11586 2/20 0.54
▸ MTHFD2 P13995 1/20 0.51
▸ KDM4E B2RXH2 1/20 0.51
▸ MEN1 O00255 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.51
▸ TYMS P04818 1/20 0.51
▸ POLB P06746 1/20 0.51
▸ GAA P10253 1/20 0.51
▸ AKR1B1 P15121 1/20 0.51
▸ HPGD P15428 1/20 0.51
▸ TSHR P16473 1/20 0.51
▸ PTGS2 P35354 1/20 0.51
▸ KMT2A Q03164 1/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ TDP1 Q9NUW8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofolate SCHEMBL15263902 1.00 SOST (0.78) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL21194977 1.00 SOST (0.78) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL4535490 1.00 SOST (0.78) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL82453 1.00 SOST (0.78) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL159230 1.00 SOST (0.78) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL6880950 1.00 SOST (0.78) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL3445556 0.99 SOST (0.77) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL21248600 0.99 SOST (0.77) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL19376762 0.99 SOST (0.77) SOSTFPGSATICGARTDHFR
Tetrahydrofolate SCHEMBL3404283 0.99 SOST (0.77) SOSTFPGSATICGARTDHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 195937 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146142-A1 WAVELENGTH DOWNCONVERTERS LAMBDA ENERGY LTD (GB) 2026-05-28 — — US claimed
US-20260146043-A1 CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE CYCLACEL PHARMACEUTICALS INC. (US) 2026-05-28 — — US claimed
US-20260146036-A1 CRYSTALLINE FORMS RAQUALIA PHARMA INC. (JP) 2026-05-28 — — US claimed
US-20260144334-A1 LIQUID THERMOPLASTIC POLYMER APPLICATION FOR FOOTWEAR UPPERS ADIDAS AG (DE) 2026-05-28 — — US claimed
US-20260147286-A1 TONER CANON KABUSHIKI KAISHA (JP) 2026-05-28 — — US claimed
US-20260146056-A1 MORPHOLINE-BASED ORGANOPHOSPHINE LIGAND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Henan Academy of Sciences Institute of Chemistry Co., Ltd (CN) 2026-05-28 — — US claimed
US-20260148848-A1 BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2026-05-28 — — US claimed
EP-4747003-A1 <SUP2/>? <SUB2/>?2?A STEAM-STABLE THREE-DIMENSIONAL (3D) ZINC-ADENINATE METAL ORGANIC FRAMEWORK WITH A HIGH SELECTIVITY FOR INDUSTRIAL COCAPTURE Svante Technologies Inc. (CA) 2026-05-27 — — EP claimed
EP-3478295-B1 SYNTHESIS OF N-(HETEROARYL)-PYRROLO[3,2-D]PYRIMIDIN-2-AMINES PHARMACOSMOS HOLDING AS (DK) 2026-05-27 — — EP claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 — — EP claimed
EP-0266042-A2 Optically active pteridine derivatives University of Strathclyde (GB) 1988-05-04 — — EP claimed
EP-0217862-A1 $i(IN VITRO) SYNTHESIS OF L-TRYPTOPHAN GENEX CORPORATION (US) 1987-04-15 — — EP claimed
WO-1986005515-A1 IN VITRO SYNTHESIS OF L-TRYPTOPHAN GENEX CORPORATION (US) 1986-09-25 — — WO claimed
EP-0185824-A1 Stabilization of tetrahydrofolic acid and serine hydroxymethyltransferase in reaction mixtures for the enzymatic cynthesis of L-serine GENEX CORPORATION (US) 1986-07-02 — — EP claimed
EP-0181902-A1 NEW COMPOSITIONS OF LIPOSOMES HAVING A SPECIFIC ACTION WITH REGARD TO THE PROLIFERATION OF GIVEN CELLS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1986-05-28 — — EP claimed
EP-0165044-A2 Method of reacting an aldehyde- containing compound with a nucleophilic compound GENEX CORPORATION (US) 1985-12-18 — — EP claimed
WO-1985005453-A1 NEW COMPOSITIONS OF LIPOSOMES HAVING A SPECIFIC ACTION WITH REGARD TO THE PROLIFERATION OF GIVEN CELLS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE M (FR) 1985-12-05 — — WO claimed
US-4372874-A Stabilization of hydrolysis prone labile organic reagents in liquid media MEDICAL ANALYSIS SYSTEMS, INC. 1983-02-08 — — US claimed
US-4206307-A SODIUM BOROHYDRIDE, NUETRALIZATION, ASCORBID ACID AS ANTIOXIDANT UNITED STATES OF AMERICA (US) 1980-06-03 — — US claimed
US-4148999-A 5-FORMYL-TETRAHYDROFOLIC ACID THE GOVERNMENT OF THE UNITED STATES OF AMERICA (US) 1979-04-10 — — US claimed
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