Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.77 |
| ▸ | FPGS | Q05932 | 2/20 | 0.69 |
| ▸ | ATIC | P31939 | 2/20 | 0.59 |
| ▸ | GART | P22102 | 4/20 | 0.57 |
| ▸ | DHFR | P00374 | 2/20 | 0.57 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.53 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TYMS | P04818 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL21194977 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL82453 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL4535490 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL8031 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL159230 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL6880950 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL15263902 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL3445556 | 0.98 | SOST (0.77) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL19376762 | 0.98 | SOST (0.77) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL9150211 | 0.98 | SOST (0.77) | SOSTFPGSATICGARTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260048054-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L E A F HOLDINGS GROUP LLC (US) | 2026-02-19 | — | — | US | disclosed |
| US-12336994-B2 | Alpha polyglutamated tetrahydrofolates and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2025-06-24 | — | — | US | disclosed |
| US-20250064736-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2025-02-27 | — | — | US | disclosed |
| US-12048766-B2 | Gamma polyglutamated tetrahydrofolates and uses thereof | L.E.A.F. HOLDINGS GROUP LLC (US) | 2024-07-30 | — | — | US | disclosed |
| US-20210346381-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC | 2021-11-11 | — | — | US | disclosed |
| US-20210128469-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F HOLDINGS GROUP LLC | 2021-05-06 | — | — | US | disclosed |
| EP-3755335-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F Holdings Group LLC (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-3749319-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F Holdings Group LLC (US) | 2020-12-16 | — | — | EP | disclosed |
| WO-2019160735-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-22 | — | — | WO | disclosed |
| WO-2019157120-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | L.E.A.F. HOLDINGS GROUP LLC (US) | 2019-08-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12336994-B2 | Alpha polyglutamated tetrahydrofolates and uses thereof | DHFR, FPGS, MTHFD1 | SOST 3884/4885FPGS 2/4885ATIC 511/4885 |
| US-12048766-B2 | Gamma polyglutamated tetrahydrofolates and uses thereof | FPGS, DHFR, MTHFD1 | SOST 3772/4885FPGS 1/4885ATIC 618/4885 |
| US-20210128469-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | FPGS, DHFR, MTHFD1 | SOST 3772/4885FPGS 1/4885ATIC 618/4885 |
| US-20260048054-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | FOLR2, FOLR1, FPGS | SOST 4468/4885FPGS 3/4885ATIC 269/4885 |
| US-20250064736-A1 | GAMMA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | FPGS, DHFR, MTHFD1 | SOST 3772/4885FPGS 1/4885ATIC 618/4885 |
| US-20210346381-A1 | ALPHA POLYGLUTAMATED TETRAHYDROFOLATES AND USES THEREOF | DHFR, FPGS, MTHFD1 | SOST 3884/4885FPGS 2/4885ATIC 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.