Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.77 |
| ▸ | FPGS | Q05932 | 2/20 | 0.69 |
| ▸ | ATIC | P31939 | 2/20 | 0.59 |
| ▸ | GART | P22102 | 4/20 | 0.57 |
| ▸ | DHFR | P00374 | 2/20 | 0.57 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.53 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TYMS | P04818 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL15263902 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL6880950 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL82453 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL8031 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL159230 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL4535490 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL21194977 | 0.99 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL21248600 | 0.98 | SOST (0.77) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL19376762 | 0.98 | SOST (0.77) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL8078001 | 0.98 | SOST (0.77) | SOSTFPGSATICGARTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7816525-B1 | Process for the preparation of optically pure tetrahydropterins and derivatives, and specifically of optically pure tetrahydrofolic acid and derivatives thereof, by stereospecific hydrogenation | Merck & Cie (CH) | 2010-10-19 | — | — | US | disclosed |
| US-20080306263-A1 | Process For The Preparation Of Optically Pure Tetrahydropterins And Derivatives, And Specifically Of Optically Pure Tetrahydrofolic Acid And Derivatives Thereof, By Stereospecific Hydrogenation | MULLER HANS RUDOLF | 2008-12-11 | — | — | US | disclosed |
| US-6858731-B1 | Process for the preparation of pure stereoisomers of tetrahydrofolic acid esters salts and tetrahydrofolic acid by fractionated crystallization of tetrahydrofolic acid esters salts | EPROVA AG (CH) | 2005-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306263-A1 | Process For The Preparation Of Optically Pure Tetrahydropterins And Derivatives, And Specifically Of Optically Pure Tetrahydrofolic Acid And Derivatives Thereof, By Stereospecific Hydrogenation | DHFR, MTHFD2, MTHFD1 | SOST 2497/4885FPGS 12/4885ATIC 70/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.