Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOST | Q9BQB4 | 1/20 | 0.78 |
| ▸ | FPGS | Q05932 | 2/20 | 0.69 |
| ▸ | ATIC | P31939 | 2/20 | 0.60 |
| ▸ | GART | P22102 | 4/20 | 0.58 |
| ▸ | DHFR | P00374 | 2/20 | 0.57 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.54 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TYMS | P04818 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofolate SCHEMBL15263902 | 1.00 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL21194977 | 1.00 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL4535490 | 1.00 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL82453 | 1.00 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL8031 | 1.00 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL159230 | 1.00 | SOST (0.78) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL3445556 | 0.99 | SOST (0.77) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL21248600 | 0.99 | SOST (0.77) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL19376762 | 0.99 | SOST (0.77) | SOSTFPGSATICGARTDHFR | |
| Tetrahydrofolate SCHEMBL3404283 | 0.99 | SOST (0.77) | SOSTFPGSATICGARTDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3949973-A2 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION | Gentelon, Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| US-20200033361-A1 | Detection and Quantitation Method for Proteomics of Post-Translational Modifications | SICHUAN UNIVERSITY (CN) | 2020-01-30 | — | — | US | disclosed |
| CN-108627647-A | A kind of detection of posttranslational modification proteomics and quantitative approach | 四川大学 | 2018-10-09 | — | — | CN | disclosed |
| EP-2948775-B1 | COMPOSITIONS AND METHODS FOR DETECTING NEOPLASIA | US HEALTH (US) | 2018-10-03 | — | — | EP | disclosed |
| WO-2018144088-A1 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION | ALEXANDER VUCKOVIC, M.D., LLC (US) | 2018-08-09 | — | — | WO | disclosed |
| US-20180104294-A1 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION | ALEXANDER VUCKOVIC, M.D., LLC (US) | 2018-04-19 | — | — | US | disclosed |
| US-9662359-B2 | Compositions and methods for treating depression | ALEXANDER VUCKOVIC, M.D., LLC (US) | 2017-05-30 | — | — | US | disclosed |
| US-20150344969-A1 | COMPOSITIONS AND METHODS FOR DETECTING NEOPLASIA | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES | 2015-12-03 | — | — | US | disclosed |
| CN-102329318-B | Preparation method of high-purity tetrahydrofolic acid | ZHEJIANG SHENGDA PHARMACEUTICAL CO LTD | 2013-07-10 | — | — | CN | disclosed |
| US-8372451-B2 | Compositions and methods for treating depression | ALEXANDER VUCKOVIC, M.D., LLC (US) | 2013-02-12 | — | — | US | disclosed |
| CN-102329318-A | Preparation method of high-purity tetrahydrofolic acid | ZHEJIANG SHENGDA PHARMACEUTICAL CO LTD | 2012-01-25 | — | — | CN | disclosed |
| WO-2011100550-A2 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION | ALEXANDER VUCKOVIC, M.D., LLC (US) | 2011-08-18 | — | — | WO | disclosed |
| US-20110200690-A1 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION | Alexander Vuckovic, M.D. LLC (US) | 2011-08-18 | — | — | US | disclosed |
| WO-2003097858-A1 | IDENTIFICATION METHOD FOR PROTECTING PRODUCTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-11-27 | — | — | WO | disclosed |
| US-5006655-A | Process for the preparation of tetrahydrofolates | EPROVA AG (CH) | 1991-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180104294-A1 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION | BHMT2, BHMT, MAT2A | SOST 3049/4885FPGS 80/4885ATIC 1550/4885 |
| US-20110200690-A1 | COMPOSITIONS AND METHODS FOR TREATING DEPRESSION | BHMT2, BHMT, MAT2A | SOST 3049/4885FPGS 80/4885ATIC 1550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.