Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 9/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049974 | 0.92 | RAB9A (0.51) | ADORA2AALOX15RAB9ANPC1TP53 | |
| SCHEMBL8041832 | 0.90 | RAB9A (0.53) | ADORA2AALOX15HSD17B10RAB9ANPC1 | |
| SCHEMBL1991055 | 0.90 | HDAC6 (0.40) | ADORA2AALOX15HPGDRAB9ANPC1 | |
| SCHEMBL8047828 | 0.89 | HDAC6 (0.44) | ADORA2ARAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL8047827 | 0.87 | NPC1 (0.41) | ADORA2AALOX15RAB9ANPC1TP53 | |
| SCHEMBL8033698 | 0.86 | SMN1; SMN2 (0.42) | ALOX15HSD17B10RAB9ANPC1TP53 | |
| SCHEMBL8050490 | 0.85 | CCNE1 (0.41) | ADORA2AALOX15HPGDHSD17B10RAB9A | |
| SCHEMBL8047833 | 0.84 | NPC1 (0.40) | ADORA2AALOX15HPGDHSD17B10RAB9A | |
| SCHEMBL8046860 | 0.83 | POLB (0.38) | ADORA2AALOX15HPGDHSD17B10RAB9A | |
| SCHEMBL8034295 | 0.79 | NPC1 (0.42) | ADORA2ARAB9ANPC1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |