Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.36 |
| ▸ | RELA | Q04206 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033858 | 0.84 | ADORA2A (0.49) | NPC1RAB9ASMN1; SMN2TP53ADORA2A | |
| SCHEMBL8033698 | 0.83 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL8049974 | 0.82 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2TP53ADORA2A | |
| SCHEMBL8050797 | 0.81 | MAPK1 (0.40) | NPC1RAB9ASMN1; SMN2TP53HDAC6 | |
| SCHEMBL8041832 | 0.81 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2TP53ADORA2A | |
| SCHEMBL1991055 | 0.80 | HDAC6 (0.40) | NPC1RAB9ASMN1; SMN2TP53ADORA2A | |
| SCHEMBL8050490 | 0.80 | CCNE1 (0.41) | NPC1RAB9ASMN1; SMN2TP53ADORA2A | |
| SCHEMBL8046860 | 0.80 | POLB (0.38) | NPC1RAB9ASMN1; SMN2TP53ADORA2A | |
| SCHEMBL8047828 | 0.79 | HDAC6 (0.44) | NPC1RAB9ASMN1; SMN2ADORA2AHDAC6 | |
| SCHEMBL8047827 | 0.78 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2TP53ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |