Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047827 | 0.90 | NPC1 (0.41) | HDAC6RAB9ANPC1SMN1; SMN2HDAC3 | |
| SCHEMBL1991055 | 0.89 | HDAC6 (0.40) | HDAC6RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8033858 | 0.89 | ADORA2A (0.49) | HDAC6RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8049974 | 0.87 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8041832 | 0.85 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8033698 | 0.83 | SMN1; SMN2 (0.42) | HDAC6RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8033057 | 0.81 | RAB9A (0.44) | HDAC6RAB9ANPC1SMN1; SMN2HDAC3 | |
| SCHEMBL8050490 | 0.80 | CCNE1 (0.41) | HDAC6RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8046860 | 0.80 | POLB (0.38) | HDAC6RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL8032670 | 0.80 | ALDH1A1 (0.51) | HDAC6RAB9ASMN1; SMN2HDAC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |