Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.51 |
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041832 | 0.94 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL8033858 | 0.92 | ADORA2A (0.49) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL8047827 | 0.89 | NPC1 (0.41) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL1991055 | 0.88 | HDAC6 (0.40) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL8047828 | 0.87 | HDAC6 (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8033698 | 0.86 | SMN1; SMN2 (0.42) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL8047833 | 0.82 | NPC1 (0.40) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL8050490 | 0.82 | CCNE1 (0.41) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL8046860 | 0.82 | POLB (0.38) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 | |
| SCHEMBL8042886 | 0.80 | KDM4E (0.44) | RAB9ANPC1SMN1; SMN2ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |