Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033698 | 0.86 | SMN1; SMN2 (0.42) | CCNE1CDK2CDK5HDAC6KDR | |
| SCHEMBL8046860 | 0.85 | POLB (0.38) | CCNE1CDK2CDK5HDAC6KDR | |
| SCHEMBL8033858 | 0.85 | ADORA2A (0.49) | HDAC6KDRSMN1; SMN2TP53NPC1 | |
| SCHEMBL8049974 | 0.82 | RAB9A (0.51) | SMN1; SMN2TP53NPC1RAB9AALOX15 | |
| SCHEMBL1991055 | 0.81 | HDAC6 (0.40) | HDAC6KDRSMN1; SMN2TP53NPC1 | |
| SCHEMBL8047828 | 0.80 | HDAC6 (0.44) | HDAC6KDRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8047833 | 0.80 | NPC1 (0.40) | CCNE1CDK2CDK5HDAC6SMN1; SMN2 | |
| SCHEMBL8041832 | 0.80 | RAB9A (0.53) | KDRSMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL8048297 | 0.79 | HDAC6 (0.45) | CCNE1CDK2CDK5HDAC6KDR | |
| SCHEMBL8047827 | 0.79 | NPC1 (0.41) | HDAC6KDRSMN1; SMN2TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |