Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | QPCT | Q16769 | 2/20 | 0.35 |
| ▸ | C1S | P09871 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043455 | 0.90 | LTA4H (0.42) | EIF4ELTA4HMEN1KMT2AKDM4E | |
| SCHEMBL8033029 | 0.85 | ATM (0.49) | ATMLTA4HMEN1KMT2AKDM4E | |
| SCHEMBL8048125 | 0.84 | CTSK (0.41) | EIF4ELTA4HKMT2AALDH1A1RAB9A | |
| SCHEMBL8044775 | 0.84 | EIF4E (0.33) | EIF4ELTA4HMEN1KMT2AKDM4E | |
| SCHEMBL8050843 | 0.84 | CTSS (0.38) | EIF4ELTA4HALDH1A1ALOX5 | |
| SCHEMBL8052850 | 0.83 | KMT2A (0.43) | EIF4EMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8050203 | 0.83 | RXRA (0.41) | EIF4EMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8033655 | 0.82 | EIF4E (0.34) | EIF4ELTA4HMEN1KMT2AKDM4E | |
| SCHEMBL8046557 | 0.82 | CTSS (0.35) | EIF4ELTA4HMEN1KMT2AKDM4E | |
| SCHEMBL8033608 | 0.81 | EIF4E (0.40) | EIF4EMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |