Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.34 |
| ▸ | ATP4B | P51164 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048125 | 0.94 | CTSK (0.41) | CTSSCTSKATP4AATP4BMAPT | |
| SCHEMBL8046557 | 0.90 | CTSS (0.35) | CTSSCTSKMAPTALDH1A1ALOX5 | |
| SCHEMBL8044775 | 0.87 | EIF4E (0.33) | CTSSCTSKHDAC3HDAC4HDAC1 | |
| SCHEMBL8033655 | 0.85 | EIF4E (0.34) | CTSSCTSKHDAC3HDAC4HDAC1 | |
| SCHEMBL8048151 | 0.84 | F2RL3 (0.37) | CTSSCTSKMAPTALDH1A1ALOX5 | |
| SCHEMBL8050203 | 0.84 | RXRA (0.41) | CTSKHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8033919 | 0.84 | ATM (0.40) | ALDH1A1ALOX5EIF4ELTA4H | |
| SCHEMBL8043408 | 0.83 | KMT2A (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8033608 | 0.81 | EIF4E (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8042665 | 0.81 | MAPT (0.41) | CTSSCTSKMAPTALOX5F2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |