Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 3/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044545 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MAPTRAB9AGAAKMT2A | |
| SCHEMBL8032728 | 0.85 | ALDH1A1 (0.37) | ALDH1A1MAPTRAB9ANPC1UBE2M | |
| SCHEMBL8050578 | 0.81 | ALDH1A1 (0.49) | ALDH1A1MAPTRAB9ANPC1GAA | |
| SCHEMBL8050969 | 0.80 | KMT2A (0.39) | ALDH1A1MAPTRAB9ANPC1GAA | |
| SCHEMBL8042957 | 0.78 | HTT (0.41) | ALDH1A1MAPTGAAKMT2AMEN1 | |
| SCHEMBL8033559 | 0.77 | LMNA (0.47) | ALDH1A1MAPTRAB9ANPC1UBE2M | |
| SCHEMBL8042707 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPTRAB9ANPC1GAA | |
| SCHEMBL8033771 | 0.77 | HSP90AA1 (0.43) | ALDH1A1MAPTRAB9ANPC1UBE2M | |
| SCHEMBL8043865 | 0.76 | RAB9A (0.42) | ALDH1A1MAPTRAB9ANPC1UBE2M | |
| SCHEMBL8033672 | 0.76 | NPSR1 (0.39) | ALDH1A1MAPTRAB9ANPC1UBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |