Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8028605 | 1.00 | POLB (0.45) | POLBPPARGHPGDALDH1A1KDM4E | |
| SCHEMBL8024501 | 0.86 | POLB (0.46) | POLBPPARGHPGDALDH1A1KDM4E | |
| SCHEMBL4537762 | 0.85 | PPARG (0.48) | PPARGHPGDALDH1A1KDM4ELMNA | |
| SCHEMBL8036319 | 0.85 | MAPT (0.49) | HPGDMAPTTHRBHTTPKM | |
| SCHEMBL8022765 | 0.83 | KCNK3 (0.50) | PPARGHDAC1KCNK3 | |
| SCHEMBL8032490 | 0.83 | PPARG (0.55) | PPARGGAAHDAC1 | |
| SCHEMBL8034326 | 0.82 | PPARG (0.48) | PPARG | |
| SCHEMBL8034344 | 0.81 | PPARG (0.54) | PPARGMAPTKCNA5HDAC1 | |
| SCHEMBL4538730 | 0.81 | PPARG (0.57) | PPARGALDH1A1KDM4EGAAMAPT | |
| SCHEMBL4537211 | 0.80 | KCNK3 (0.50) | PPARGMAPTHDAC1KCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009083526-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-07-09 | — | — | WO | disclosed |