Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.77 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.31 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | GPR183 | P32249 | 1/20 | 0.31 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL10651632 | 0.89 | MEN1 (0.71) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL11556010 | 0.89 | MEN1 (0.71) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL7193959 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL28216031 | 0.88 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL975 | 0.88 | — | — | |
| Tromethamine SCHEMBL17484 | 0.88 | MEN1 (1.00) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL3696191 | 0.88 | — | — | |
| Tromethamine SCHEMBL8897504 | 0.86 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL3817927 | 0.86 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL571834 | 0.85 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025327-A1 | CONJUGATES OF TUBULYSIN DERIVATIVES AND CELL BINDING MOLECULES AND METHODS OF MAKING | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-01-26 | — | — | US | claimed |
| EP-3991752-A1 | CELL-BINDING MOLECULE-TUBULYSIN DERIVATIVE CONJUGATE AND PREPARATION METHOD THEREFOR | Hangzhou Dac Biotech Co., Ltd (CN) | 2022-05-04 | — | — | EP | claimed |
| US-20230025327-A1 | CONJUGATES OF TUBULYSIN DERIVATIVES AND CELL BINDING MOLECULES AND METHODS OF MAKING | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-01-26 | — | — | US | disclosed |
| EP-3991752-A1 | CELL-BINDING MOLECULE-TUBULYSIN DERIVATIVE CONJUGATE AND PREPARATION METHOD THEREFOR | Hangzhou Dac Biotech Co., Ltd (CN) | 2022-05-04 | — | — | EP | disclosed |
| EP-1216417-A1 | QUANTITATIVE ANALYSIS AND TYPIFICATION OF SUBCELLULAR PARTICLES | Evotec OAI AG (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023894-A1 | QUANTITATIVE ANALYSIS AND TYPIFICATION OF SUBCELLULAR PARTICLES | EVOTEC OAI AG (DE) | 2001-04-05 | — | — | WO | disclosed |
| US-4746516-A | STORAGE STABILITY, PURITY | FARMITALIA CARLO ERBA S.P.A. (IT) | 1988-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025327-A1 | CONJUGATES OF TUBULYSIN DERIVATIVES AND CELL BINDING MOLECULES AND METHODS OF MAKING | TEK, TEKT1, EPCAM | MEN1 401/4885LMNA 3161/4885KMT2A 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.