Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022424 | 0.84 | LMNA (0.42) | APPMAPTHPGDLMNACYP3A4 | |
| SCHEMBL8038341 | 0.83 | SMO (0.38) | MAPTHPGDLMNAKDM4EGAA | |
| SCHEMBL8035761 | 0.80 | THRA (0.38) | APPHPGDCYP3A4GAAKMT2A | |
| SCHEMBL8032035 | 0.79 | APP (0.40) | APPMAPTHPGDLMNAGAA | |
| SCHEMBL8034162 | 0.79 | LRRK2 (0.38) | APPMAPTHPGDLMNACYP3A4 | |
| SCHEMBL8036048 | 0.78 | KDM1A (0.43) | APPMAPTHPGDLMNACYP3A4 | |
| SCHEMBL8028301 | 0.77 | APP (0.39) | APPMAPTHPGDLMNACYP3A4 | |
| SCHEMBL8037239 | 0.77 | CFTR (0.47) | APPMAPTHPGDLMNACYP3A4 | |
| SCHEMBL8038358 | 0.77 | HPGD (0.39) | APPHPGDKDM4ELRRK2ALDH1A1 | |
| SCHEMBL8023147 | 0.77 | APP (0.46) | APPHPGDCYP3A4KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009081892-A1 | NOVEL CATECHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, AND USE OF THOSE | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-02 | — | — | WO | disclosed |