Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031421 | 0.95 | SIGMAR1 (0.48) | NPC1RAB9ASIGMAR1TP53KDM4E | |
| SCHEMBL8029935 | 0.92 | SIGMAR1 (0.59) | SIGMAR1KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL8029639 | 0.90 | SIGMAR1 (0.50) | NPC1RAB9ASIGMAR1TP53KDM4E | |
| SCHEMBL8033363 | 0.87 | HRH3 (0.49) | NPC1RAB9ASIGMAR1TP53HPGD | |
| SCHEMBL8031455 | 0.84 | SIGMAR1 (0.53) | NPC1RAB9ASIGMAR1TP53KDM4E | |
| SCHEMBL8029642 | 0.82 | SIGMAR1 (0.54) | NPC1RAB9ASIGMAR1TP53KDM4E | |
| SCHEMBL8029877 | 0.82 | SIGMAR1 (0.50) | NPC1SIGMAR1TP53KDM4EMEN1 | |
| SCHEMBL8029908 | 0.80 | SIGMAR1 (0.53) | NPC1RAB9ASIGMAR1KDM4EMEN1 | |
| SCHEMBL8029869 | 0.78 | ALDH1A1 (0.53) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7995558 | 0.78 | LTA4H (0.46) | ALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5691340-A | CENTRAL NERVOUS SYSTEM DISORDERS, STROKES, CARDIOVASCULAR DISORDERS, ALZHEIMER*S DISEASE OR ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-11-25 | — | — | US | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |