Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL103468 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL12367675 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL10791 | 0.78 | ALDH1A1 (0.52) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL2677860 | 0.75 | ALDH1A1 (0.48) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL12802471 | 0.75 | — | — | |
| SCHEMBL8951223 | 0.75 | ALDH1A1 (0.48) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL12489264 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL7932103 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL965723 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDMMP1MMP2MMP3 | |
| SCHEMBL7977006 | 0.72 | ALDH1A1 (0.46) | ALDH1A1HPGDMMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108766-A1 | GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER ' S DISEASE | SCHERING CORPORATION (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009076337-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2009032277-A1 | GAMMA SECRETASE MODULATORS | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |