Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 16/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 14/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045249 | 0.97 | TMEM97 (0.48) | SIGMAR1TMEM97ACKR3NPC1HPGD | |
| SCHEMBL8035853 | 0.85 | DRD2 (0.48) | SIGMAR1TMEM97NPC1HPGDRAB9A | |
| SCHEMBL8053417 | 0.85 | SIGMAR1 (0.47) | SIGMAR1TMEM97ACKR3NPC1RAB9A | |
| SCHEMBL8046943 | 0.83 | CCR6 (0.47) | SIGMAR1TMEM97ACKR3NPC1HPGD | |
| SCHEMBL8035914 | 0.82 | HDAC1 (0.41) | SIGMAR1TMEM97NPC1HPGDRAB9A | |
| SCHEMBL10566240 | 0.82 | ALDH1A1 (0.50) | HRH1ALDH1A1LMNA | |
| SCHEMBL8787135 | 0.81 | KDM4E (0.48) | NPC1HPGDRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8046351 | 0.81 | NPC1 (0.51) | NPC1HPGDRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8045277 | 0.81 | NPC1 (0.51) | SIGMAR1NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8048207 | 0.81 | SIGMAR1 (0.45) | SIGMAR1TMEM97ACKR3NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | claimed |
| US-5792791-A | FOR PREVENTION AND TREATMENT OF SEROTONERGIC NEURON-RELATED DISEASES; HYPOTENSIVE AGENTS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1998-08-11 | — | — | US | claimed |
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| US-5792791-A | FOR PREVENTION AND TREATMENT OF SEROTONERGIC NEURON-RELATED DISEASES; HYPOTENSIVE AGENTS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1998-08-11 | — | — | US | disclosed |
| EP-0679649-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVE | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-11-02 | — | — | EP | disclosed |