Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 5/20 | 0.37 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785791 | 0.88 | ALDH1A1 (0.41) | ALDH1A1ALOX15F10JAK2JAK1 | |
| SCHEMBL784932 | 0.87 | F10 (0.37) | ALDH1A1ALOX15F10JAK2JAK1 | |
| SCHEMBL785218 | 0.87 | GPR119 (0.39) | GPR119F10KDM4DUSP30JAK2 | |
| SCHEMBL785217 | 0.87 | GPR119 (0.39) | GPR119F10KDM4DUSP30JAK2 | |
| SCHEMBL784500 | 0.86 | ALDH1A1 (0.39) | ALDH1A1ALOX15F10JAK2JAK1 | |
| SCHEMBL803454 | 0.85 | CTSS (0.41) | GPR119ALDH1A1F10USP30JAK2 | |
| SCHEMBL785867 | 0.85 | CYP3A4 (0.38) | ALDH1A1ALOX15F10JAK2JAK1 | |
| SCHEMBL784362 | 0.84 | ALDH1A1 (0.38) | ALDH1A1ALOX15F10USP30JAK2 | |
| SCHEMBL784953 | 0.84 | POLB (0.39) | ALDH1A1ALOX15F10CCR5 | |
| SCHEMBL784256 | 0.84 | CCR5 (0.38) | ALDH1A1ALOX15F10JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | GPR119 698/4885ALDH1A1 1267/4885ALOX15 2120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.