SCHEMBL803658

SCHEMBL803658

O=C(O)CCCc1ccc(C(=O)O)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.72
SMN1; SMN2 Q16637 2/20 0.67
HDAC3 O15379 1/20 0.67
MAPK1 P28482 1/20 0.67
ADRA1A P35348 1/20 0.67
HDAC4 P56524 1/20 0.67
SLC6A3 Q01959 1/20 0.67
HDAC1 Q13547 1/20 0.67
HDAC7 Q8WUI4 1/20 0.67
HDAC2 Q92769 1/20 0.67
HDAC10 Q969S8 1/20 0.67
HDAC11 Q96DB2 1/20 0.67
HDAC8 Q9BY41 1/20 0.67
HDAC6 Q9UBN7 1/20 0.67
HDAC9 Q9UKV0 1/20 0.67
HDAC5 Q9UQL6 1/20 0.67
RARB P10826 6/20 0.59
FFAR1 O14842 1/20 0.58
MAPT P10636 3/20 0.57
RXFP1 Q9HBX9 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13131603 0.94 MAPT (0.66) HSD17B10SMN1; SMN2HDAC3MAPK1ADRA1A
SCHEMBL11569566 0.92 MAPT (0.69) HSD17B10SMN1; SMN2HDAC3MAPK1ADRA1A
SCHEMBL12834782 0.92 MAPT (0.69) HSD17B10SMN1; SMN2HDAC3MAPK1ADRA1A
SCHEMBL6208836 0.89 SMN1; SMN2 (0.82) HSD17B10SMN1; SMN2HDAC3MAPK1ADRA1A
SCHEMBL264975 0.87 FFAR1 (0.65) HSD17B10RARBFFAR1ALDH1A1TSHR
SCHEMBL371605 0.87 RARB (0.71) HSD17B10SMN1; SMN2HDAC1HDAC8RARB
SCHEMBL133470 0.87 RARB (0.68) HSD17B10HDAC1HDAC8RARBMAPT
SCHEMBL69789 0.87 SMN1; SMN2 (0.78) HSD17B10SMN1; SMN2HDAC3MAPK1ADRA1A
SCHEMBL9472454 0.85 RARB (0.72) HSD17B10HDAC1RARBMAPTRXFP1
SCHEMBL30053056 0.85 RARB (0.72) HSD17B10HDAC1RARBMAPTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105785713-B Photosensitive resin composition, dry film, cured product, member or product, and adhesive 太阳控股株式会社 2022-06-03 CN disclosed
US-9688737-B2 Protease stabilized acylated insulin analogues NOVO NORDISK A/S (DK) 2017-06-27 US disclosed
US-9512195-B2 Insulin derivatives containing additional disulfide bonds NOVO NORDISK A/S (DK) 2016-12-06 US disclosed
US-20150210747-A1 PROTEASE STABILIZED ACYLATED INSULIN ANALOGUES NOVO NORDISK AS (DK) 2015-07-30 US disclosed
US-9045560-B2 Protease stabilized, acylated insulin analogues NOVO NORDISK A/S (DK) 2015-06-02 US disclosed
US-20140371140-A1 Insulin derivatives Containing Additional Disulfide bonds NOVO NORDISK AS (DK) 2014-12-18 US disclosed
US-8680159-B2 Bradykinin 1 receptor modulating compounds GRUENENTHAL GMBH (DE) 2014-03-25 US disclosed
US-8680159-B2 Bradykinin 1 receptor modulating compounds GRUENENTHAL GMBH (DE) 2014-03-25 US disclosed
US-20140073564-A1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES NOVO NORDISK A/S (DK) 2014-03-13 US disclosed
WO-2012038081-A1 SUBSTITUTED BENZAMIDE COMPOUNDS Grünenthal GmbH (DE) 2012-03-29 WO disclosed
US-5635477-A CYCLIC TETRAPEPTIDE DERIVATIVE FUSED TO A BENZENE RING; ANTICOAGULANTS; THROMBOLYTICS; CLOT LYSIS THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) 1997-06-03 US disclosed
EP-0699209-A1 PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-03-06 EP disclosed
EP-0692982-A1 RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-24 EP disclosed
EP-0691987-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-17 EP disclosed
WO-1995023811-A1 NOVEL CARBOCYCLIC COMPOUNDS WHICH INHIBIT PLATELET AGGREGATION BY INTERACTION WITH THE GPIIB/IIIA RECEPTOR COMPLEX THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1995-09-08 WO disclosed
WO-1994026779-A1 PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-11-24 WO disclosed
EP-0625164-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-11-23 EP disclosed
WO-1994022910-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-10-13 WO disclosed
WO-1994022494-A1 RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1994-10-13 WO disclosed
WO-1993007170-A1 CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-04-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150210747-A1 PROTEASE STABILIZED ACYLATED INSULIN ANALOGUES IAPP, IDE, LIPE HSD17B10 405/4885SMN1; SMN2 1218/4885HDAC3 302/4885
US-20140073564-A1 PROTEASE STABILIZED, ACYLATED INSULIN ANALOGUES IAPP, IDE, LIPE HSD17B10 455/4885SMN1; SMN2 1083/4885HDAC3 381/4885
US-20140371140-A1 Insulin derivatives Containing Additional Disulfide bonds IAPP, IGFBP4, INSR HSD17B10 129/4885SMN1; SMN2 3459/4885HDAC3 2002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.