Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | EYA2 | O00167 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081887 | 0.84 | LOXL2 (0.39) | LOXL2ALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL8507588 | 0.81 | LOXL2 (0.37) | LOXL2ALDH1A1MEN1TSHRTBXA2R | |
| SCHEMBL7815658 | 0.79 | CYP3A4 (0.40) | CYP2C19CYP2C9ALDH1A1CYP3A4HPGD | |
| SCHEMBL2089679 | 0.77 | LOXL2 (0.40) | LOXL2ALDH1A1CYP1A2HPGDMCL1 | |
| SCHEMBL8038421 | 0.77 | LOXL2 (0.40) | LOXL2CYP2C19ALDH1A1CYP1A2HPGD | |
| SCHEMBL26423718 | 0.73 | GABRA1 (0.52) | LOXL2GABRA1GABRB2CYP2C19CYP2C9 | |
| SCHEMBL7830992 | 0.72 | ALDH1A1 (0.49) | ALDH1A1MEN1MAPTTSHRMAPK1 | |
| SCHEMBL1855422 | 0.72 | GPR52 (0.53) | MAPTHTR2AHTR2BKMT2AMAOB | |
| SCHEMBL12093432 | 0.71 | LOXL2 (0.47) | LOXL2GABRA1GABRB2ALDH1A1MEN1 | |
| SCHEMBL29450783 | 0.71 | LOXL2 (0.47) | LOXL2GABRA1GABRB2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060508-A | FOR TREATING URINARY STRESS INCONTINENCE, GASTROINTESTINAL DISORDERS, ULCERS, MIGRAINES | SYNTHELABO (FR) | 2000-05-09 | — | — | US | disclosed |
| EP-0923567-A1 | BENZYLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SYNTHELABO (FR) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008834-A1 | BENZYLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS | SYNTHELABO (FR) | 1998-03-05 | — | — | WO | disclosed |