Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28242263 | 1.00 | — | — | |
| Bicarbonate SCHEMBL31571631 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL31571632 | 0.94 | CA4 (0.42) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL8059663 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL1331961 | 0.94 | — | — | |
| Bicarbonate SCHEMBL532723 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL121569 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL711064 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL3261 | 0.94 | — | — | |
| Bicarbonate SCHEMBL9145494 | 0.94 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111780911-B | Ultrasonic sensor for measuring bolt axial force | 零声科技(苏州)有限公司 | 2022-05-24 | — | — | CN | claimed |
| CN-111871747-B | Capacitance-sensing type electromagnetic ultrasonic transducer | 零声科技(苏州)有限公司 | 2021-09-17 | — | — | CN | claimed |
| CN-111871747-A | Capacitance-sensing type electromagnetic ultrasonic transducer | 零声科技(苏州)有限公司 | 2020-11-03 | — | — | CN | claimed |
| CN-111780911-A | Ultrasonic sensor for measuring bolt axial force | 零声科技(苏州)有限公司 | 2020-10-16 | — | — | CN | claimed |
| EP-4466247-A1 | METHOD FOR PRODUCING HESPERETIN DIHYDROCHALCONE | Symrise AG (DE) | 2024-11-27 | — | — | EP | disclosed |
| US-20240376035-A1 | METHOD FOR PRODUCING HESPERETIN DIHYDROCHALCONE | SYMRISE AG (DE) | 2024-11-14 | — | — | US | disclosed |
| CN-118632829-A | Process for preparing hesperetin dihydrochalcone | 西姆莱斯有限公司 | 2024-09-10 | — | — | CN | disclosed |
| CN-116495944-B | Method and device for treating industrial wastewater in membrane production | 湖南沁森高科新材料有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-116495944-A | Method and device for treating industrial wastewater in membrane production | 湖南沁森高科新材料有限公司 | 2023-07-28 | — | — | CN | disclosed |
| WO-2023139225-A1 | METHOD FOR PRODUCING HESPERETIN DIHYDROCHALCONE | SYMRISE AG (DE) | 2023-07-27 | — | — | WO | disclosed |
| WO-2023138777-A1 | METHOD FOR PRODUCING HESPERETIN DIHYDROCHALCONE | SYMRISE AG (DE) | 2023-07-27 | — | — | WO | disclosed |
| CN-111780911-B | Ultrasonic sensor for measuring bolt axial force | 零声科技(苏州)有限公司 | 2022-05-24 | — | — | CN | disclosed |
| CN-106152130-A | A kind of two-way combination type burner | 宁波市鄞州姜山盛旺五金厂 | 2016-11-23 | — | — | CN | disclosed |
| CN-106086518-A | Copper alloy and application thereof containing nisiloy cobalt | 宁波博威合金板带有限公司 | 2016-11-09 | — | — | CN | disclosed |
| EP-2875063-A1 | NOVEL POLYAMIDE, PREPARATION PROCESS THEREFOR AND USES THEREOF | Rhodia Operations (FR) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014012829-A1 | NOVEL POLYAMIDE, PREPARATION PROCESS THEREFOR AND USES THEREOF | RHODIA OPERATIONS (FR) | 2014-01-23 | — | — | WO | disclosed |
| US-6039978-A | HOMOGENOUS FREE-FLOWING POWDER FOOD ENHANCING AGENT WITH CALCIUM, MAGNESIUM PHOSPHOROUS USING DICALCIUM PHOSPHATE, CALCIUM CITRATE AND MAGNESIUM PHOSPHATE | CAMPBELL SOUP COMPANY (US) | 2000-03-21 | — | — | US | disclosed |
| US-6039989-A | PREPACKAGED THERAPUTIC MEALS FOR DIETS | CAMPBELL SOUP COMPANY (US) | 2000-03-21 | — | — | US | disclosed |
| US-5994295-A | ADMINISTERING PREPACKAGED MEALS | CAMPBELL SOUP COMPANY (US) | 1999-11-30 | — | — | US | disclosed |
| US-5977059-A | THERAPY FOR DIET RESPONSIVE CONDITIONS | CAMPBELL SOUP COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240376035-A1 | METHOD FOR PRODUCING HESPERETIN DIHYDROCHALCONE | DHPS, HES1, NISCH | CA4 2312/4885CA1 2788/4885FAHD1 3617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.