SCHEMBL8038465

SCHEMBL8038465

CC(C)CNC(=O)c1ccc(C2(F)CC2c2ccc(Cl)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.48
NPC1 O15118 1/20 0.48
ALDH1A1 P00352 1/20 0.48
LMNA P02545 1/20 0.48
ALOX12 P18054 1/20 0.48
KCNH2 Q12809 1/20 0.48
HPGD P15428 2/20 0.45
MLYCD O95822 1/20 0.45
KDM4E B2RXH2 1/20 0.43
EPHX2 P34913 4/20 0.42
NPSR1 Q6W5P4 1/20 0.41
P2RX7 Q99572 1/20 0.41
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PRMT5 O14744 2/20 0.40
GAA P10253 1/20 0.40
HSD17B10 Q99714 1/20 0.40
P2RX3 P56373 1/20 0.40
GPR139 Q6DWJ6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8036366 0.88 MLYCD (0.47) RAB9ANPC1ALDH1A1ALOX12KCNH2
SCHEMBL8034310 0.84 MLYCD (0.43) ALDH1A1LMNAHPGDMLYCDKDM4E
SCHEMBL8040729 0.78 RAB9A (0.57) RAB9ANPC1ALDH1A1LMNAALOX12
SCHEMBL8036360 0.78 ALOX15 (0.50) ALDH1A1
SCHEMBL8038470 0.76 POLB (0.48) RAB9ANPC1LMNAHPGDKMT2A
SCHEMBL8036313 0.75 MAOA (0.40) RAB9ALMNAHPGDKMT2AMEN1
SCHEMBL8780006 0.71 NAMPT (0.38) HPGDP2RX7KMT2AMEN1
SCHEMBL17865783 0.71 MLYCD (0.73) RAB9ANPC1ALDH1A1LMNAALOX12
SCHEMBL17660271 0.70 MLYCD (0.56) RAB9ANPC1ALDH1A1LMNAALOX12
SCHEMBL15087817 0.68 MEN1 (0.58) RAB9ANPC1ALDH1A1LMNAALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6159973-A Aromatic amides, their preparation process, the compositions containing them and their use as pesticides HOECHST SCHERING AGREVO S.A. (FR) 2000-12-12 US disclosed
EP-0805795-B1 NOVEL AROMATIC AMIDES, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS PESTICIDES HOECHST SCHERING AGREVO SA (FR) 2000-08-23 EP disclosed
US-6013837-A E.G.,4-(2-(3,4,5-TRICHLORO PHENYL) 1-FLUOROCYCLOPROPYL)-N-(2-METHYL PHENYL)BENZAMIDE; PARTICULAR USE AGAINST ARTHROPODS, HELMINTHS AND MOLLUSCS; INSECTICIDES; ACARICIDES; NEMATICIDES; PHOTOSTABILITY; NONTOXIC TO MAMMALS HOECHST MARION ROUSSEL (FR) 2000-01-11 US disclosed
EP-0805795-A1 NOVEL AROMATIC AMIDES, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS PESTICIDES Hoechst Schering AgrEvo S.A. (FR) 1997-11-12 EP disclosed
WO-1996022965-A1 NOVEL AROMATIC AMIDES, METHOD FOR PREPARING AND COMPOSITIONS CONTAINING SAME, AND USE THEREOF AS PESTICIDES HOECHST SCHERING AGREVO S.A. (FR) 1996-08-01 WO disclosed