Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14421919 | 0.83 | PNMT (0.42) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL8426347 | 0.83 | PNMT (0.38) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL8039779 | 0.81 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL7390944 | 0.78 | GRIN2B (0.41) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL8026316 | 0.76 | HRH3 (0.38) | RAB9ANPC1MAPTLMNA | |
| SCHEMBL8038096 | 0.75 | CA2 (0.38) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL16190023 | 0.75 | TDP1 (0.53) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL12862897 | 0.75 | LOXL2 (0.41) | MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL28876770 | 0.75 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CMEN1 | |
| SCHEMBL28284898 | 0.75 | PNMT (0.43) | PNMTADRA2AADRA2BADRA2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000076990-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |