Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333424 | 0.84 | SIGMAR1 (0.40) | SIGMAR1CXCR4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20443304 | 0.83 | MEN1 (0.42) | SIGMAR1CXCR4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL19709244 | 0.82 | KMT2A (0.42) | SMN1; SMN2MEN1KMT2ALTA4HHRH3 | |
| SCHEMBL18874679 | 0.82 | KMT2A (0.39) | SMN1; SMN2MEN1KMT2ALTA4HHRH3 | |
| SCHEMBL23183570 | 0.81 | SIGMAR1 (0.38) | SIGMAR1CXCR4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL23987984 | 0.81 | CXCR4 (0.52) | SIGMAR1CXCR4SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18735503 | 0.80 | PSMB1 (0.45) | MEN1KMT2AHRH3 | |
| SCHEMBL20328741 | 0.80 | ALDH1A1 (0.42) | SIGMAR1MEN1KMT2ALTA4HHRH3 | |
| SCHEMBL21016198 | 0.79 | CXCR4 (0.41) | SIGMAR1CXCR4MEN1KMT2AHRH2 | |
| SCHEMBL20231018 | 0.78 | HSD11B1 (0.37) | SMN1; SMN2KMT2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | UNIV YALE (US) | 2023-12-14 | — | — | US | disclosed |
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | UNIV YALE (US) | 2023-12-14 | — | — | US | disclosed |
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2021-04-06 | — | — | US | disclosed |
| US-20190276425-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2019-09-12 | — | — | US | disclosed |
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2019-07-02 | — | — | US | disclosed |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2018-06-28 | — | — | US | disclosed |
| EP-0527051-B1 | Quinophthalone dyes, ink composition and transfer sheet containing them | MITSUI CHEMICALS INC (JP) | 2000-03-22 | — | — | EP | disclosed |
| US-5387686-A | Sublimable, yellow quinoline derivatives; storage stable; heat light, chemical resistant | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1995-02-07 | — | — | US | disclosed |
| US-5296445-A | Quinoline dyes | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1994-03-22 | — | — | US | disclosed |
| EP-0527051-A1 | Quinophthalone dyes, ink composition and transfer sheet containing them | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1993-02-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | SIGMAR1 4096/4885CXCR4 181/4885SMN1; SMN2 4652/4885 |
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | SIGMAR1 4096/4885CXCR4 181/4885SMN1; SMN2 4652/4885 |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | MIF, MMP12, CSF1R | SIGMAR1 4096/4885CXCR4 181/4885SMN1; SMN2 4652/4885 |
| US-20190276425-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | MIF, MMP12, CSF1R | SIGMAR1 4096/4885CXCR4 181/4885SMN1; SMN2 4652/4885 |
| US-20230399303-A1 | Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same | MIF, MMP12, METAP1 | SIGMAR1 4229/4885CXCR4 481/4885SMN1; SMN2 3388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.