Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 5/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | RXRG | P48443 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031094 | 0.81 | MAPK1 (0.47) | HPGDMAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8044819 | 0.72 | TSHR (0.40) | DHODHRAB9ASMN1; SMN2RXRBRXRA | |
| SCHEMBL8044749 | 0.70 | PIN1 (0.44) | NPC1RAB9AMEN1KMT2ARXRB | |
| SCHEMBL4829038 | 0.68 | ALDH1A1 (0.56) | HPGDSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL12359714 | 0.68 | ALDH1A1 (0.56) | HPGDSMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2479933 | 0.66 | ALDH1A1 (0.52) | HPGDMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL31417705 | 0.66 | ALDH1A1 (0.52) | HPGDMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL2251499 | 0.66 | ALDH1A1 (0.52) | HPGDMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL11888126 | 0.66 | ALDH1A1 (0.52) | HPGDMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL8043075 | 0.65 | DHODH (0.43) | HPGDDHODHRXRBRXRARXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686144-B1 | NEW COMPOUNDS | UNIV MARYLAND (US) | 2000-04-19 | — | — | EP | disclosed |
| US-5688945-A | Compounds | ASTRA AKTIEBOLAG (SE) | 1997-11-18 | — | — | US | disclosed |
| US-5661183-A | 3-hydroxy anthanilic acid derivatives | THE UNIVERSITY OF MARYLAND (US) | 1997-08-26 | — | — | US | disclosed |
| EP-0686144-A1 | NEW COMPOUNDS | Astra Aktiebolag (SE) | 1995-12-13 | — | — | EP | disclosed |
| WO-1994019315-A1 | NEW COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1994-09-01 | — | — | WO | disclosed |