Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044746 | 0.83 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8042494 | 0.80 | HDAC6 (0.56) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL8033687 | 0.78 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8033751 | 0.78 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8043814 | 0.77 | NPC1 (0.38) | USP7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8050654 | 0.75 | NPC1 (0.36) | NPC1RAB9AMEN1KMT2AAGTR1 | |
| SCHEMBL8043447 | 0.75 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8048020 | 0.75 | HCAR2 (0.56) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8042788 | 0.73 | HSD17B10 (0.42) | RXRARXRBRXRGHCAR2NPC1 | |
| SCHEMBL8050732 | 0.72 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |