Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041815 | 0.81 | MEN1 (0.33) | NPC1RAB9AMEN1AGTR1KMT2A | |
| SCHEMBL8048062 | 0.77 | KDM4E (0.58) | NPC1RAB9ASMN1; SMN2LMNATSHR | |
| SCHEMBL8050654 | 0.77 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL8041975 | 0.77 | RXRA (0.45) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL8051212 | 0.76 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TSHRMEN1 | |
| SCHEMBL8032709 | 0.75 | HTT (0.41) | SMN1; SMN2LMNATP53TSHRMEN1 | |
| SCHEMBL8047637 | 0.75 | LMNA (0.39) | SMN1; SMN2LMNATP53USP7 | |
| SCHEMBL8042291 | 0.72 | USP7 (0.30) | USP7 | |
| SCHEMBL8044080 | 0.70 | ALDH1A1 (0.40) | NPC1RAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL8044478 | 0.69 | MEN1 (0.40) | NPC1RAB9ASMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |