Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LIG1 | P18858 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049983 | 0.83 | RXRA (0.39) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8050237 | 0.83 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8043545 | 0.83 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8045389 | 0.83 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8044846 | 0.81 | RAB9A (0.42) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8046142 | 0.80 | RXRA (0.38) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8043417 | 0.77 | HDAC6 (0.36) | RXRARXRBRXRGKDM4EDAO | |
| SCHEMBL8033057 | 0.76 | RAB9A (0.44) | RXRARXRBRXRGALDH1A1 | |
| SCHEMBL8041975 | 0.75 | RXRA (0.45) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8033751 | 0.75 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |