Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834843 | 0.82 | ESR1 (0.37) | ESR1PTGS1PDE4A | |
| SCHEMBL8038860 | 0.82 | ESR1 (0.37) | ESR1PTGS1PDE4A | |
| SCHEMBL8042493 | 0.82 | SMN1; SMN2 (0.31) | HTTALDH1A1SMN1; SMN2GLA | |
| SCHEMBL8834929 | 0.82 | SMN1; SMN2 (0.31) | HTTALDH1A1SMN1; SMN2GLA | |
| SCHEMBL9428111 | 0.77 | ELANE (0.36) | KMT2AMEN1SMN1; SMN2ESR1PTGS1 | |
| SCHEMBL9428941 | 0.76 | CACNA1C (0.36) | ESR1PTGS1PDE4A | |
| SCHEMBL9427855 | 0.76 | CACNA1C (0.36) | ESR1PTGS1PDE4A | |
| SCHEMBL8046094 | 0.76 | LMNA (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL8039549 | 0.75 | ESR1 (0.33) | ALDH1A1ESR1PTGS1PDE4A | |
| SCHEMBL8046007 | 0.74 | CACNA1C (0.36) | LMNAESR1PTGS1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587436-B1 | Process for preparing carbapenem and penem compounds and new compounds involved in that process | SANKYO CO (JP) | 2000-05-10 | — | — | EP | disclosed |
| US-5614624-A | THIO SUBSTITUTED, ANTIBIOTICS, CHEMICAL INTERMEDIATES | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| US-5541317-A | PENICILLIN DERIVATIVES, CYCLIZATION OF ESTERS OR THIOESTERS | SANKYO COMPANY, LIMITED (JP) | 1996-07-30 | — | — | US | disclosed |