Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043019 | 0.84 | HDAC6 (0.38) | HDAC6SMN1; SMN2MAPTTSHRPOLB | |
| SCHEMBL8042860 | 0.83 | HDAC6 (0.44) | HDAC6SMN1; SMN2RAB9ANPC1PTK2 | |
| SCHEMBL8043654 | 0.81 | TSHR (0.52) | HDAC6SMN1; SMN2MAPTTSHRNPSR1 | |
| SCHEMBL8043237 | 0.81 | TSHR (0.39) | HDAC6MAPTPKMTSHRPOLB | |
| SCHEMBL8045350 | 0.80 | SMN1; SMN2 (0.39) | HDAC6SMN1; SMN2MAPTTP53NFKB1 | |
| SCHEMBL8044387 | 0.80 | TSHR (0.37) | HDAC6MAPTPKMTSHRPOLB | |
| SCHEMBL8042913 | 0.80 | ALDH1A1 (0.44) | HDAC6SMN1; SMN2MAPTTP53NFKB1 | |
| SCHEMBL8042586 | 0.79 | RPA1 (0.47) | HDAC6SMN1; SMN2MAPTTP53NFKB1 | |
| SCHEMBL8047165 | 0.79 | NPC1 (0.44) | SMN1; SMN2MAPTRAB9ANPC1TSHR | |
| SCHEMBL8049866 | 0.78 | PKM (0.45) | HDAC6SMN1; SMN2MAPTPKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |