Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SDHB | P21912 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048108 | 0.90 | KMT2A (0.40) | KMT2AMEN1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL8050203 | 0.86 | RXRA (0.41) | KMT2AMEN1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8048125 | 0.84 | CTSK (0.41) | KMT2AMAPTALDH1A1L3MBTL1TDP1 | |
| SCHEMBL8047523 | 0.83 | PARP1 (0.53) | KMT2AMEN1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL8050843 | 0.83 | CTSS (0.38) | MAPTALDH1A1L3MBTL1HDAC3HDAC4 | |
| SCHEMBL8044775 | 0.82 | EIF4E (0.33) | KMT2AMEN1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL8042404 | 0.82 | MAPT (0.45) | KMT2AMEN1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL8046557 | 0.81 | CTSS (0.35) | KMT2AMEN1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL8033608 | 0.80 | EIF4E (0.40) | KMT2AMEN1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8033655 | 0.79 | EIF4E (0.34) | KMT2AMEN1MAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |