Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 14/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114230 | 0.75 | FBP1 (0.70) | FBP1PDK1HTR7FDPSFLT3 | |
| SCHEMBL8718458 | 0.70 | FBP1 (0.35) | FBP1PDK1 | |
| SCHEMBL8033034 | 0.67 | FBP1 (0.47) | FBP1PDK1HTR7FDPSFLT3 | |
| SCHEMBL4195087 | 0.66 | — | — | |
| SCHEMBL909645 | 0.65 | METAP1 (0.41) | FBP1PDK1ALDH1A1TSHRNOS1 | |
| SCHEMBL10504608 | 0.65 | DDAH1 (0.50) | NOS1 | |
| SCHEMBL191350 | 0.65 | FBP1 (1.00) | FBP1PDK1HTR7FDPSSMN1; SMN2 | |
| SCHEMBL8051506 | 0.64 | ALDH1A1 (0.53) | FBP1PDK1HTR7SMN1; SMN2ALDH1A1 | |
| SCHEMBL10532248 | 0.64 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL8038016 | 0.63 | HTT (0.46) | FBP1PDK1SMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |