Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28442955 | 0.82 | CCR2 (0.53) | CCR2KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL9666902 | 0.80 | CCR2 (0.61) | CCR2KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL9740521 | 0.78 | SMN1; SMN2 (0.67) | KMT2ASMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL27903386 | 0.78 | LMNA (0.44) | KMT2AHPGDLMNAALDH1A1HTT | |
| SCHEMBL27990355 | 0.78 | L3MBTL1 (0.59) | CCR2KMT2AALDH1A1HTTPOLB | |
| SCHEMBL28165404 | 0.78 | MCL1 (0.41) | KMT2ASMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL30049411 | 0.77 | HDAC1 (0.62) | CCR2KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL6821030 | 0.77 | HDAC1 (0.62) | CCR2KMT2AHPGDSMN1; SMN2LMNA | |
| SCHEMBL28164991 | 0.77 | APP (0.38) | KMT2AHPGDALDH1A1HTTTP53 | |
| SCHEMBL28164979 | 0.77 | MTNR1A (0.37) | KMT2AHPGDSMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106928121-A | The high efficiency preparation method of 3- substitution-benzo five-membered heterocycle -2- carbonyls | 暨南大学 | 2017-07-07 | — | — | CN | disclosed |
| WO-1999044604-A9 | PHARMACEUTICAL COMPOSITIONS CONTAINING THE PHOSPHOLIPASE INHIBITOR SODIUM [[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-PHENYLMETHYL)-1H-INDOL-4-YL]OXY]ACETATE | SHIONOGI & CO (JP) | 2000-01-20 | — | — | WO | disclosed |
| US-5245046-A | α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0375133-A1 | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1990-06-27 | — | — | EP | disclosed |
| WO-1990005721-A1 | ALPHA-AMINO-INDOLE-3-ACETIC ACIDS USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | disclosed |