Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033626 | 0.91 | KMT2A (0.42) | HTTSMN1; SMN2NPSR1KDM4ETDP1 | |
| SCHEMBL8047470 | 0.89 | ALDH1A1 (0.40) | HTTSMN1; SMN2NPSR1KDM4ETDP1 | |
| SCHEMBL8043221 | 0.88 | PDK1 (0.44) | HTTSMN1; SMN2NPSR1KDM4ETDP1 | |
| SCHEMBL8042500 | 0.87 | KDM4E (0.38) | HTTSMN1; SMN2NPSR1KDM4ETDP1 | |
| SCHEMBL8044246 | 0.85 | ALDH1A1 (0.39) | HTTSMN1; SMN2NPSR1KDM4ETDP1 | |
| SCHEMBL8034272 | 0.84 | ALDH1A1 (0.41) | HTTSMN1; SMN2NPSR1KDM4ETDP1 | |
| SCHEMBL8715778 | 0.82 | HTT (0.42) | HTTSMN1; SMN2NPSR1ALDH1A1HPGD | |
| SCHEMBL8044438 | 0.82 | ALDH1A1 (0.41) | HTTSMN1; SMN2NPSR1KDM4ETDP1 | |
| SCHEMBL8043961 | 0.81 | ALDH1A1 (0.42) | HTTSMN1; SMN2NPSR1ALDH1A1GAA | |
| SCHEMBL8052232 | 0.81 | ALDH1A1 (0.43) | HTTSMN1; SMN2NPSR1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |