Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033626 | 0.91 | KMT2A (0.42) | HTTSMN1; SMN2NPSR1KMT2ALMNA | |
| SCHEMBL8043682 | 0.82 | HTT (0.50) | HTTSMN1; SMN2NPSR1KMT2ALMNA | |
| SCHEMBL8047470 | 0.81 | ALDH1A1 (0.40) | HTTSMN1; SMN2NPSR1KMT2ALMNA | |
| SCHEMBL8043221 | 0.80 | PDK1 (0.44) | HTTSMN1; SMN2NPSR1KMT2ALMNA | |
| SCHEMBL8043930 | 0.78 | KMT2A (0.44) | HTTSMN1; SMN2NPSR1KMT2ALMNA | |
| SCHEMBL8051030 | 0.77 | HTT (0.43) | HTTSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL8041875 | 0.77 | GPR84 (0.45) | HTTSMN1; SMN2NPSR1KMT2ALMNA | |
| SCHEMBL8044702 | 0.77 | ALDH1A1 (0.44) | HTTSMN1; SMN2KMT2ALMNATP53 | |
| SCHEMBL8043083 | 0.76 | HTT (0.43) | HTTSMN1; SMN2NPSR1KMT2ALMNA | |
| SCHEMBL8051920 | 0.76 | TSHR (0.51) | HTTSMN1; SMN2NPSR1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |