SCHEMBL8042500

SCHEMBL8042500

Cc1ccc(S(=O)(=O)Cc2nnc(Sc3nc4c(Cl)cccc4s3)n2-c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
HTT P42858 4/20 0.38
NPSR1 Q6W5P4 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
ALDH1A1 P00352 5/20 0.37
HPGD P15428 2/20 0.37
MAPT P10636 4/20 0.35
LMNA P02545 4/20 0.35
NPC1 O15118 1/20 0.35
POLB P06746 1/20 0.35
GAA P10253 4/20 0.35
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
USP2 O75604 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
ALOX15 P16050 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8043682 0.87 HTT (0.50) KDM4ETDP1HTTNPSR1SMN1; SMN2
SCHEMBL8720215 0.83 HTT (0.48) HTTNPSR1SMN1; SMN2HSP90AA1HSP90AB1
SCHEMBL8044246 0.81 ALDH1A1 (0.39) KDM4ETDP1HTTNPSR1SMN1; SMN2
SCHEMBL8044438 0.81 ALDH1A1 (0.41) KDM4ETDP1HTTNPSR1SMN1; SMN2
SCHEMBL8033626 0.81 KMT2A (0.42) KDM4ETDP1HTTNPSR1SMN1; SMN2
SCHEMBL8034272 0.80 ALDH1A1 (0.41) KDM4ETDP1HTTNPSR1SMN1; SMN2
SCHEMBL8044489 0.79 PKM (0.38) HTTNPSR1SMN1; SMN2HSP90AA1ALDH1A1
SCHEMBL8047470 0.79 ALDH1A1 (0.40) KDM4ETDP1HTTNPSR1SMN1; SMN2
SCHEMBL8043221 0.78 PDK1 (0.44) KDM4ETDP1HTTNPSR1SMN1; SMN2
SCHEMBL8043961 0.77 ALDH1A1 (0.42) HTTNPSR1SMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080772-A 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY SUGEN, INC. (US) 2000-06-27 US disclosed