Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050637 | 0.92 | HDAC6 (0.49) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8043471 | 0.88 | KDM4E (0.41) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8044404 | 0.82 | ATM (0.44) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8042056 | 0.81 | FBP1 (0.51) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8041816 | 0.80 | RAB9A (0.47) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8052850 | 0.78 | KMT2A (0.43) | KMT2AMEN1RAB9AKDM4EALOX5 | |
| SCHEMBL8033022 | 0.77 | ALDH1A1 (0.54) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL4281217 | 0.77 | RAB9A (0.75) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL11455457 | 0.77 | RAB9A (0.75) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL8032807 | 0.76 | MEN1 (0.45) | KMT2AMEN1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |