Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | UBE2M | P61081 | 11/20 | 0.50 |
| ▸ | DCUN1D1 | Q96GG9 | 11/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042704 | 0.89 | DCUN1D1 (0.44) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8033580 | 0.88 | POLB (0.44) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8034187 | 0.85 | HTR1A (0.44) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8033682 | 0.85 | RAB9A (0.45) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8043688 | 0.83 | HTR1A (0.46) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8043614 | 0.83 | DCUN1D1 (0.41) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8043865 | 0.82 | RAB9A (0.42) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8042045 | 0.82 | UBE2M (0.46) | UBE2MDCUN1D1 | |
| SCHEMBL8041849 | 0.81 | RAB9A (0.38) | HTR1AHTR7HTR2AUBE2MDCUN1D1 | |
| SCHEMBL8720492 | 0.80 | RAB9A (0.41) | HTR1AHTR7HTR2AUBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |