Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 11/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | UBE2M | P61081 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044049 | 0.89 | HTR1A (0.54) | DCUN1D1UBE2MMAPTNPC1RAB9A | |
| SCHEMBL8046481 | 0.88 | ALDH1A1 (0.44) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL8044646 | 0.86 | ALDH1A1 (0.52) | DCUN1D1MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL8032462 | 0.85 | CYP2C19 (0.39) | DCUN1D1MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL8043207 | 0.83 | MAPT (0.44) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL8051108 | 0.82 | KMT2A (0.38) | DCUN1D1KDM1AMAPTALDH1A1NPC1 | |
| SCHEMBL8720492 | 0.82 | RAB9A (0.41) | DCUN1D1UBE2MALDH1A1NPC1RAB9A | |
| SCHEMBL8043614 | 0.81 | DCUN1D1 (0.41) | DCUN1D1UBE2MHTR1AHTR7HTR2A | |
| SCHEMBL8042146 | 0.80 | KDM4E (0.42) | DCUN1D1UBE2MMAPTNPC1RAB9A | |
| SCHEMBL8042045 | 0.80 | UBE2M (0.46) | DCUN1D1KDM1AUBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |