Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8055620 | 0.84 | HDAC1 (0.37) | GABRA5GABRB2HSD17B10HDAC6HDAC1 | |
| SCHEMBL2411987 | 0.81 | HSD17B10 (0.61) | GABRA5GABRB2HSD17B10 | |
| SCHEMBL8538449 | 0.78 | MAPT (0.54) | — | |
| SCHEMBL2655261 | 0.78 | GABRA5 (0.68) | GABRA5GABRB2HSD17B10HDAC6HDAC1 | |
| SCHEMBL2642866 | 0.76 | — | — | |
| SCHEMBL8538010 | 0.75 | HDAC6 (0.47) | GABRA5GABRB2HSD17B10HDAC6HDAC1 | |
| SCHEMBL5512924 | 0.74 | SLC6A3 (0.47) | GABRA5GABRB2HSD17B10HDAC6HDAC1 | |
| SCHEMBL8062319 | 0.73 | HDAC1 (0.36) | HSD17B10HDAC6HDAC1 | |
| SCHEMBL9749078 | 0.73 | APEX1 (0.50) | GABRA5GABRB2HSD17B10HDAC6HDAC1 | |
| SCHEMBL9749270 | 0.73 | L3MBTL1 (0.39) | GABRA5GABRB2HSD17B10HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150351-A | ADMINISTERING AN EFFECTIVE AMOUNT OF THE CEPHEM COMPOUND TO A PATIENT SUFFERING FROM DISEASES CAUSED BY HELICOBACTER PYLORI | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-21 | — | — | US | disclosed |
| EP-0882052-A1 | NEW CEPHEM COMPOUNDS AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997029111-A1 | NEW CEPHEM COMPOUNDS AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-14 | — | — | WO | disclosed |
| EP-0397048-B1 | Process for the preparation of 2-mercapto-4-methyl-1,3-thiazol-5-yl acetic acid and its esters | HOECHST AG (DE) | 1994-08-31 | — | — | EP | disclosed |