Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050209 | 0.85 | RXRA (0.43) | RXRARXRBRXRGHCAR2ALDH1A1 | |
| SCHEMBL8051764 | 0.83 | RXRA (0.41) | RXRARXRBRXRGHCAR2GAA | |
| SCHEMBL8044684 | 0.83 | RXRA (0.42) | RXRARXRBRXRGHCAR2GAA | |
| SCHEMBL8042939 | 0.82 | RXRA (0.41) | RXRARXRBRXRGHCAR2GAA | |
| SCHEMBL8046385 | 0.82 | RXRA (0.41) | RXRARXRBRXRGHCAR2TSHR | |
| SCHEMBL8044736 | 0.81 | RXRA (0.40) | RXRARXRBRXRGHCAR2MAPK8 | |
| SCHEMBL8044449 | 0.80 | SMN1; SMN2 (0.43) | RXRARXRBRXRGHCAR2TSHR | |
| SCHEMBL8043440 | 0.80 | F2 (0.43) | RXRARXRBRXRGHCAR2GAA | |
| SCHEMBL8043212 | 0.80 | RXRA (0.39) | RXRARXRBRXRGHCAR2GAA | |
| SCHEMBL8048020 | 0.79 | HCAR2 (0.56) | RXRARXRBRXRGHCAR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |