Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044684 | 0.93 | RXRA (0.42) | RXRARXRBRXRGHCAR2KDM4E | |
| SCHEMBL8050209 | 0.88 | RXRA (0.43) | RXRARXRBRXRGHCAR2KDM4E | |
| SCHEMBL8044736 | 0.86 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8043212 | 0.85 | RXRA (0.39) | RXRARXRBRXRGHCAR2ALDH1A1 | |
| SCHEMBL8051764 | 0.83 | RXRA (0.41) | RXRARXRBRXRGHCAR2L3MBTL1 | |
| SCHEMBL8044854 | 0.83 | RXRA (0.39) | RXRARXRBRXRGHCAR2KDM4E | |
| SCHEMBL8042939 | 0.82 | RXRA (0.41) | RXRARXRBRXRGHCAR2L3MBTL1 | |
| SCHEMBL8032493 | 0.82 | RAB9A (0.44) | KDM4EALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL8044327 | 0.82 | RXRA (0.41) | RXRARXRBRXRGHCAR2ALDH1A1 | |
| SCHEMBL8044449 | 0.80 | SMN1; SMN2 (0.43) | RXRARXRBRXRGHCAR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |