Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032934 | 0.89 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2ALMNATSHR | |
| SCHEMBL8044541 | 0.84 | ALOX15 (0.41) | ALDH1A1MEN1KMT2ALMNARAB9A | |
| SCHEMBL8051238 | 0.83 | HSD17B10 (0.42) | ALDH1A1KMT2ALMNATSHRRAB9A | |
| SCHEMBL8044066 | 0.82 | HTT (0.45) | ALDH1A1MEN1KMT2ALMNATSHR | |
| SCHEMBL8042994 | 0.82 | GABRA5 (0.41) | ALDH1A1MEN1KMT2ALMNARAB9A | |
| SCHEMBL8033559 | 0.81 | LMNA (0.47) | ALDH1A1MEN1KMT2ALMNATSHR | |
| SCHEMBL8051833 | 0.80 | POLB (0.54) | ALDH1A1MEN1KMT2ALMNATSHR | |
| SCHEMBL8043865 | 0.80 | RAB9A (0.42) | ALDH1A1MEN1KMT2ALMNATSHR | |
| SCHEMBL8043765 | 0.80 | L3MBTL1 (0.41) | ALDH1A1LMNATSHRRAB9ASMN1; SMN2 | |
| SCHEMBL8033866 | 0.80 | HSD17B10 (0.40) | ALDH1A1LMNATDP1HSD17B10GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |